Publications
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2006 Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW.
A Genomewide Search for Ribozymes Reveals an HDF-Like Sequence in the Human CPEB3 Gene.
Science September 22, 2006 PDF
Hanzyc MM, Mansy SS, Szostak JW.
Mineral Surface Directed Membrane Assembly.
Orig. Life Evol. Biosph. July 1, 2006 PDF
Carothers JM, Oestreich SC, Szostak JW .
Aptamers Selected for Higher-Affinity Binding Are Not More Specific for the Target Ligand.
JACS May 27, 2006 PDF
Seebeck F., Szostak JW.
Ribosomal Synthesis of Dehydroalanin-Containing Peptides.
JACS May 13, 2006 PDF
Hartman MCT, Josephson K, Szostak JW.
Enzymatic aminoacylation of tRNA with unnatural amino acids.
PNAS March 13, 2006 PDF
Carothers JM, Davis JH, Chou JJ, Szostak JW.
Solution structure of an informationally complex high-affinity RNA aptamer to GTP.
RNA Journal February 28, 2006 PDF
Cho GS, Szostak JW.
Directed Evolution of ATP Binding Proteins from a Zinc Finger Domain by Using mRNA Display.
Chemistry and Biology February 2006 PDF
2005
Josephson K, Hartman MC, Szostak JW.
Ribosomal synthesis of unnatural peptides.
J Am Chem Soc. 2005 Aug 24;127(33):11727-35.
PDF Supporting Information
Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC.
Kinetic analysis of an efficient DNA-dependent TNA polymerase.
J Am Chem Soc. 2005 May 25;127(20):7427-34. PDF Supporting Information
Shen X, Valencia CA, Szostak JW, Dong B, Liu R.
Scanning the human proteome for calmodulin-binding proteins.
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5969-74. PDF Supporting Information
Sacerdote MG, Szostak JW.
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose.
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6004-8. PDF Supporting Information
Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW.
Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).
Org Lett. 2005 Apr 14;7(8):1485-7. PDF Supporting Information Supporting Information
Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW.
An in vitro selection system for TNA.
J Am Chem Soc. 2005 Mar 9;127(9):2802-3. PDF Supporting Information [top]
2004
Hanczyc MM, Szostak JW.
Replicating vesicles as models of primitive cell growth and division.
Curr Opin Chem Biol. 2004 Dec;8(6):660-4. PDF
Chen, IA, Roberts, RW, Szostak, JW.
The emergence of competition between model protocells.
Science 2004 Sep 3;305:1474-76. PDF Supporting Information
Chen IA, Szostak JW.
A kinetic study of the growth of fatty acid vesicles.
Biophys J. 2004 Aug;87(2):988-98. PDF
Sazani PL, Larralde R, Szostak JW.
A small aptamer with strong and specific recognition of the triphosphate of ATP.
J Am Chem Soc. 2004 Jul 14;126(27):8370-1. PDF Supporting Information
Chaput JC, Szostak JW.
Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability.
Chem Biol. 2004 Jun;11(6):865-74. PDF
Chen IA, Szostak JW.
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles.
Proc Natl Acad Sci U S A. 2004 May 25;101(21):7965-70. PDF
Carothers JM, Oestreich SC, Davis JH, Szostak JW.
Informational complexity and functional activity of RNA structures.
J Am Chem Soc. 2004 Apr 28;126(16):5130-7.
PDF Supporting Information Extra Materials [top]
2003
Hanczyc, MM, Fujikawa, SM, Szostak, JW.
Experimental models of primitive cellular compartments: encapsulation, growth, and division.
Science. 2003 Oct 24; 302: 618-622. PDF
Chaput, JC, Szostak, JW.
TNA synthesis by DNA polymerases.
J Am Chem Soc. 2003 Aug 6;125(31):9274-5. PDF
Vaish, NK, Larralde, R. Fraley, AW, Szostak, JW, McLaughlin, LW.
A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality.
Biochemistry. 2003 Jul 29;42(29):8842-51. PDF
Szostak, JW.
Functional information: molecular messages.
Nature. 2003 June 12; 423:
689. PDF
Huang, Z, and Szostak, JW.
Selective labeling and detection of specific RNAs in an RNA mixture.
Anal Biochem. 2003 Apr 1;315(1):129-33. PDF
Chaput, JC, Ichida, JK, Szostak, JW.
DNA polymerase-mediated DNA synthesis on a TNA template.
J Am Chem Soc. 2003 Jan 29;125(4):856-7. PDF [top]
2002
Davis, JH, Szostak, JW.
Isolation of high-affinity GTP aptamers from partially structured RNA libraries.
Proc Natl Acad Sci U S A. 2002 Sep 3; 99(18):11616-11621. PDF
Burgstaller P, Hale S, Sun L, Roberts RW, Szostak JW, Wagner R.
Identification of epitope-like consensus motifs using mRNA display.
J Mol Recognit. 2002 May-Jun;15(3):126-34. [top]
2001
Salehi-Ashtiani K, Szostak JW.
In vitro evolution suggests multiple origins for the hammerhead ribozyme.
Nature. 2001 Nov 1;414(6859):82-4. PDF
Szostak JW, Bartel, DP and Luisi, PL.
Synthesizing Life.
Nature. 2001; 409: 387-390. PDF
Keefe AD, Szostak JW.
Functional proteins from a random-sequence library.
Nature. 2001 Apr 5;410(6829):715-8. PDF
Keefe AD, Wilson, DS, Seelig, B, and Szostak JW.
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.
Protein Expression and Purification. 2001; 28 : 440-446. PDF
Wilson DS, Keefe AD, Szostak JW.
The use of mRNA display to select high-affinity protein-binding peptides.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3750-5. PDF [top]
2000
Vaish, NK, Fraley, AW, Szostak, JW, McLaughlin, LW.
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids.
Nucleic Acids Res. 2000 Sep 1;28(17):3316-22. PDF
Cho, G, Keefe, AD, Wilson, DS, Liu, R and Szostak, JW.
Constructing high complexity synthetic libraries of long ORFs using in vitro selection.
J.Mol.Biol. 2000; 297:309-319 PDF Download supplementary information here.
Vaish NK, Fraley AW, Szostak JW, McLaughlin LW.
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids.
Nucleic Acids Res. 2000 Sep 1;28(17):3316-22. PDF
Lee N, Bessho Y, Wei K, Szostak JW, Suga H.
Ribozyme-catalyzed tRNA aminoacylation.
Nat Struct Biol. 2000 Jan;7(1):28-33. PDF
Liu R, Barrick JE, Szostak JW, Roberts RW.
Optimized synthesis of RNA-protein fusions for in vitro protein selection.
Methods Enzymol. 2000;318:268-93. [top]
1999
Szostak JW.
Constraints on the sizes of the earliest cells.
In 'Size Limits of Very Small Microorganisms', Proceedings of a Workshop of the Space Studies Board, National Research Council. 1999, National Academy Press.
Wilson DW, Szostak JW.
In vitro Selection of Functional Nucleic Acids.
Ann. Rev. Biochem., 1999; 68:611-648. PDF [top]
1998
Szostak JW.
In Vitro Selection and Directed Evolution.
1998 Harvey Lecture Series. 1997-98;93:95-118. Review.
Holeman LA, Robinson SL, Szostak JW and Wilson C.
Isolation and characterization of fluorophore-binding RNA aptamers.
Folding & Design, 1998; 3:423-431.
Wilson C, Szostak JW.
Isolation of a fluorophore-specific DNA aptamer with weak redox activity.
Chem. Biol., 1998; 5: 609-617.
Wilson C, Nix J, Szostak JW.
Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot.
Biochemistry 1998; 37:14410-9. PDF
Suga H, Cowan JA, Szostak JW.
Unusual metal ion catalysis in an acyl transferase ribozyme.
Biochemistry 1998; 37:10118-10125. PDF
Suga H, Lohse P, Szostak JW.
Structural and Kinetic Characterization of an Acyl Transferase Ribozyme.
J. Am. Chem. Soc. 1998; 120: 1151-1156. PDF [top]
1997
Roberts RW, Szostak JW.
RNA-peptide fusions for the in Vitro selection of peptides and proteins.
Proc. Natl. Acad. Sci. USA 1997; 94: 12297-12302. PDF
Hager AJ, Szostak JW.
Isolation of Novel Ribozymes that Ligate AMP-Activated RNA Substrates.
Chem. Biol. 1997; 4:607-617.
Dieckmann T, Butcher SE, Sassanfar M, Szostak JW and Feigon J.
Mutant ATP-Binding RNA aptamers reveal the structural basis for ligand binding.
J. Mol. Biol. 1997; 273: 467- 478. PDF
Szostak JW.
Introduction: Combinatorial Chemistry.
Chem. Rev. 1997; 97 (2): 347-348, in: Chemical Reviews: Combinatorial Chemistry, a Thematic Issue, Guest Editor Jack W. Szostak. [top]
1996
Hager AJ, Pollard JD, Szostak JW.
Ribozymes: aiming at RNA replication and translation.
Chem. Biol. 1996; 3:717-725.
Huang Z, Szostak JW.
3' End-Labeling of RNA with DNA Polymerase.
Nuc. Acids Res. 1996; 24: 4360-4361. PDF
Lohse P, Szostak JW.
Ribozyme-catalysed amino acid transfer reactions.
Nature 1996; 381: 442-444.
Rohatgi R, Bartel D, Szostak JW.
Non-enzymatic, Template-Directed Ligation of Oligoribonucleotides is Highly Regioselective for the Formation of 3'-5' Phosphodiester Bonds.
J. Am. Chem. Soc. 1996; 118: 3340-3334. PDF
Rohatgi R, Bartel D, Szostak JW.
Kinetic and Mechanistic Analysis of Nonenzymatic, Template-Directed Oligonucleotide Ligation.
J. Am. Chem. Soc. 1996; 118: 3332-3339 PDF
Lorsch JR, Szostak JW.
Chance and Necessity in the Selection of Nucleic Acid Catalysts.
Accounts Chem. Res. 1996; 29: 103-110. PDF
Lorsch JR, Szostak JW.
In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules.
1996. Ch. 4 in Combinatorial Libraries: Synthesis, Screening and Application Potential. Ed. R. Cortese. Publ. Walter de Gruyter, Berlin, New York. [top]
1995
Lorsch JR, Bartel DP, Szostak JW.
Reverse transcriptase reads through a 2'-5' linkage and a 2'-thiophosphate in a template.
Nuc. Acids Res. 1995; 23: 2811-2814.
Ekland EH, Szostak JW, Bartel DP.
Structurally complex and highly active RNA ligases derived from random RNA sequences.
Science 1995; 269: 364-370. PDF
Cuenod B, Szostak JW.
A DNA metalloenzyme with DNA ligase activity.
Nature 1995; 375: 611-614.
Chapman KB, Szostak JW.
Isolation of a ribozyme with 5'-5' ligase activity.
Chemistry and Biology 1995; 2: 325-333.
Wilson CW, Szostak JW.
In vitro evolution of a self-alkylating ribozyme.
Nature 1995; 374: 777-782.
Whoriskey S, Usman N, Szostak JW.
Total chemical synthesis of a ribozyme derived from a group I intron.
Proc. Natl. Acad. Sci. U.S.A. 1995; 92: 2465-2469.
Lauhon CT, Szostak JW.
RNA Aptamers that bind Flavin and Nicotinamide Redox Cofactors.
J. Am. Chem. Soc. 1995; 117: 1246-1257. PDF
Huizenga DE, Szostak JW.
DNA Aptamer that Binds Adenosine and ATP.
Biochemistry 1995; 34: 656-665. [top]
1994
Bartel DP, Szostak JW.
Study of RNA-protein recognition by in vitro selection.
In RNA- Protein Interactions, eds. K. Nagai and I.W. Mattaj, Oxford University Press 1994.
Hanna M, Szostak JW.
Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization.
Nuc. Acids Res. 1994; 22: 5326-5331.
Lorsch JR, Szostak JW.
In vitro evolution of new ribozymes with polynucleotide kinase activity.
Nature 1994; 371:31-36.
Chapman KB, Szostak JW.
In Vitro Selection of Catalytic RNAs.
Current Opinions in Structural Biology 1994; 4:618-622.
Green R, Szostak JW.
Template-directed oligonucleotide assembly reactions catalyzed by a minimally structured ribozyme derived from a group I intron.
pp. 277-283 in, Structural Biology: The State of the Art, Proceedings of the Eighth Conversation, State University of New York, Albany, NY 1993 Eds. Ramaswamy H. Sarma and Mukti H. Sarma, Adenine Press 1994
Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J. H
NMR Studies of the High- Affinity Rev Binding Site of the Rev Responsive Element of HIV-1 mRNA: Base Pairing in the Core Binding Element.
Biochemistry 1994; 33: 5357-5366.
Lorsch J, Szostak, JW.
In Vitro Selection of RNA Aptamers Specific for Cyanocobalamin.
Biochemistry 1994; 33:973-982.
Lin, C-W, Szostak JW.
Evidence That the Guanosine Substrate of the Tetrahymena Ribozyme is Bound in the Anti Conformation and That N7 Contributes to Binding.
Biochemistry 1994; 33:2703-2707.
Green R, Szostak JW.
In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.
J. Mol. Biol. 1994; 235:140-155. [top]
1993
Bartel DP, Szostak JW.
Isolation of new ribozymes from a large pool of random sequences.
Science 1993; 261:1411-1418. PDF
Sassanfar M, Szostak JW.
An RNA motif that binds ATP.
Nature 1993; 364: 550-553.
Famulok M, Szostak JW.
Selection of Functional RNA and DNA Molecules from Randomized Sequences.
pp. 271-284, in Nucleic Acids and Molecular Biology, ed. F. Eckstein and D.M.J. Lilley, Springer-Verlag, 1993.
Szostak, J.W. and Ellington, A.E.
In Vitro Selection of Functional RNA Sequences.
pp. 511-533 in "The RNA World", ed. R. Gesteland and J. Atkins; Cold Spring Harbor Press, 1993.
Doudna JA, Szostak JW.
Triplet extension: a novel strategy for RNA catalysed RNA replication.
Biochemistry 1993; 32:2111-2115. [top]
1992
Green R and Szostak JW.
Selection of a Ribozyme that Functions as a Superior Template in a Self-Copying Reaction.
Science1992; 258:1910-1915. PDF
Wilson CL, Szostak JW.
Ribozyme Catalysis.
Curr. Opin. in Struct. Biol. 1992; 2:749-756.
Famulok M, Szostak JW.
In Vitro Selection of Specific Ligand Binding Nucleic Acids.
Angew. Chem. Int. Ed. Engl. 1992; 31: 979-988.
Famulok M, Szostak JW.
Stereospecific Recognition of Tryptophan Agarose by in Vitro Selected RNA.
J. Am. Chem. Soc. 1992; 114: 3990-3991.
Szostak JW.
In Vitro Genetics.
Trends in Biochem. Sci. 1992; 17: 89-93.
Ellington AE, Szostak JW.
Selection in vitro of single-stranded DNA molecules that fold into specific ligand binding structures.
Nature 1992; 355:850-852. [top]
1991
Green R, Szostak JW, Benner SA, Rich A, Usman N.
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice-site of the Tetrahymena group I intron.
Nuc. Acids Res., 1991; 19: 4161-4166.
Bartel DP, Zapp M, Green M, Szostak JW.
HIV-1 Rev Regulation Involves Recognition of Non-Watson-Crick Base-pairs in Viral RNA.
Cell, 1991; 67: 529-536.
Green R, Ellington AD, Bartel DP, Szostak JW.
In Vitro Genetic Analysis: Selection and Amplification of Rare Functional Nucleic Acids.
Methods: A Companion to Methods in Enzymol., 1991; 2: 75-86.
Bartel DP, Szostak JW.
Template-Directed Primer Extension Catalyzed by the Tetrahymena Ribozyme.
Mol. Cell. Biol. 1991; 11: 3390-3394.
Doudna JA, Couture S, Szostak JW.
A multi-subunit ribozyme that is a catalyst of and a template for complementary strand RNA synthesis.
Science 1991; 251: 1605-1608. [top]
1990
Doudna JA, Szostak JW, Rich A, Usman N.
Chemical Synthesis of Oligoribonucleotides Containing 2-Aminopurine: Substrates for the Investigation of Ribozyme Function.
J. Org. Chem. 1990; 55: 5547-5549.
Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajogopal J, Szostak JW.
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.
Nature, 1990; 347: 578-580.
Ellington AE, Szostak JW.
In vitro Selection of RNA Molecules that Bind Specific Ligands.
Nature, 1990; 346: 818-822. [top]
1989
Michel F, Hanna M, Green R, Bartel DB, Szostak JW.
Miniribozymes, Small Derivatives of the sunY Intron, Are Catalytically Active.
Mol. Cell. Biol. 1989; 9: 5480-5483.
Doudna JA, Szostak JW.
Stereochemical Course of Catalysis by the Tetrahymena Ribozyme.
Science, 1989; 244: 692-694. [top]
1987
Doudna JA, Cormack BP, Szostak JW.
Genetic Dissection of an RNA Enzyme.
Cold Spring Harbor Symposia, Vol. LII. 1987.
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