Ruvkun Lab
Publications
   

Publications

Recent Publications (2001 to the present)

  1. Cahill, C.M., Tzivion, G., Nasrin, N., Ogg, S., Dore, J., Ruvkun, G., and M. Alexander-Bridges. 2001. PI-3 kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3 dependent and independent pathways. J. Biol. Chem. 276: 13402-10.

  2. Reinhart, B.J. and G. Ruvkun. 2001. Isoform-specific mutations in the Caenorhabitis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 157: 199-209.

  3. Bürglin, T.R. and G. Ruvkun 2001. Regulation of ectodermal and excretory cell function by the C. elegans POU homeobox gene ceh-6 Development 128: 779-790.

  4. Pierce, S.B., Costa, M., Wisotzkey, R. , Devadhar, S., Homburger, S.A., Buchman, A.R., Ferguson, K.C., Heller, J., Platt, D.M. , Liu, L.X. , Pasquinelli, A.E., Doberstein, S.K. , G. Ruvkun. 2001. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes and Development 15: 672-686.

  5. Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D.L., Fire, A., Ruvkun, G., and Mello, C.C. 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control Caenorhabditis elegans developmental timing. Cell 106: 23-34.

  6. Finch, C.E. and G. Ruvkun. 2001. The Genetics of Aging. Ann. Rev. Genomics and Human Genetics 2: 435-462

  7. Ruvkun, G. 2001. Glimpses of the tiny RNA world. Science 294:797-9.

  8. Lee, R.Y.N., Hench, J., and G. Ruvkun. 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 11: 1950-1957.

  9. Sze, J.Y., Zhang, S., Li, J., and G. Ruvkun. 2002 The C elegans POU-domain transcription factor UNC-86 regulates the tph-1 hydroxylase gene and neurite outgrowth in particular serotonergic neurons. Development, 129:3901-11

  10. Pasquinelli, A.E. and G. Ruvkun. 2002. Control of developmental timing by microRNAs and their targets. Ann. Rev. Cell Biology., 18:495-513.

  11. Ruvkun, G., M. Finney, G. Church, M. Zuber, W. Gilbert. 2002. A Robotic-PCR Detector for DNA-based Life on Other Planets, in Signs of Life: A Report based on the April 2000 Workshop on Life Detection Techniques. Space Sciences Board, NASA.

  12. Lee S.S, and Ruvkun G. 2002. Longevity: don't hold your breath. Nature. 418:287-8.

  13. Wolkow CA, Munoz MJ, Riddle DL, G. Ruvkun. 2002. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 277:49591-7.

  14. Lee, S.S., Lee, R.Y., Fraser, AG, Kamath, RS, Ahringer, J. and G Ruvkun 2002. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics, 33:40-8.

  15. Ashrafi, K., Chang, FY,.Watts, JL, Fraser, AG, Kamath, RS, Ahringer, J. and G. Ruvkun 2003. Genome-wide RNAi analysis of C. elegans fat regulatory genes. Nature, 421:268-72.

  16. Li, W. and G. Ruvkun 2003. daf-28 encodes a C. elegans insulin-like ligand that acts in the DAF-2 insulin like signaling pathway and is regulated by environmental cues. Genes and Development, 17: 844-58.

  17. Bashirullah, A., Pasquinelli, A.E. Kiger, A., Perrimon, N, Ruvkun, G., and C. S. Thummel. 2003. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Developmental Biology, 259:1-8.

  18. Pasquinelli, A.E., McCoy, A. Jimenez, E. , Salo, E., , Ruvkun, G. , Martindale, M. Q. and J. Baguñà 2003. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: A role in life history evolution? Evolution and Development, 5:372-378.

  19. Aspöck, G, Ruvkun, G,, and T. R. Bürglin. 2003. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development, 130:3369-3378.

  20. Lee, S.S., Kennedy,S., Tolonen,A.C. and G. Ruvkun. 2003. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 300: 644-7

  21. Grad, Y., Aach, J., Hayes, G.D., Reinhart, B. , Church, G. M. , Ruvkun, G., and J. Kim. 2003. Computational and experimental identification of C. elegans microRNAs. Molecular Cell, 11:1253-63.

  22. Garsin, D.A. J. M. Villanueva1,, J. Begun, D. H. Kim1, C. D. Sifri, S. B. Calderwood, G. Ruvkun,and F. M. Ausubel,, 2003. Long-Lived Caenorhabditis elegans daf-2 Mutants are Resistant to Bacterial Pathogens, Science, 300:1921.

  23. Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. 2003. A uniform system for microRNA annotation. RNA. 9: 277-279.

  24. Ruvinsky, I. and G. Ruvkun 2003. Functional tests of enhancer conservation between distantly related species, Development, 130:5133-42.

  25. Sze, J.Y. and G. Ruvkun. 2003. Olfactory hypersensitivity and hyperadaptation in C. elegans caused by activation of the UNC-86 POU transcription factor, Proc. Natl. Acad. Sci., 100:9560-5.

  26. Komaroff AL, Ruvkun G. 2003 . Unraveling the secrets of the cell. Newsweek.Dec 8; 142: 96.

  27. Kim, J , Krichevsky, A., Grad, Y., Hayes, G.D., Kosik, K.S. , Church, G. M. , and G. Ruvkun. 2004. Identification of many mammalian neuron-expressed microRNAs that co-purify with polysomes, Proc. Natl. Acad. Sci.101: 360-5.

  28. Ruvkun, G., B. Wightman, and I. Ha. 2004. The 20 years it took to recognize the importance of tiny RNAs. Cell S116: S93–S96,

  29. Kennedy, S.K., D. Wang, and G. Ruvkun. 2004. A conserved siRNA degrading RNase negatively regulates RNA interference in C. elegans Nature 427: 645-9..

  30. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M.. 2004. Systematic genetic perturbation analysis of a Caenorhabditis elegans TGF-ß protein interaction network. Molecular Cell 13:469-82.

  31. Mak, H. Y. and G. Ruvkun. 2004. Cell nonautonomous role of DAF-9 cytochrome P450 in C. elegans larval development and gonadal migration. Development, 131:1777-86.

  32. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. 2004. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 36:1079-83

  33. Ruvkun, G., J. Kim, G. Hayes, S. Kennedy, D. Wang, K. Ashrafi. 2004. The Tiny RNA World. Harvey Lecture 99: 1-21.

  34. Wang, D. and G. Ruvkun. 2004. The insulin pathway regulates RNAi in C. elegans. Cold Spring Harbor Symposium on Quantitative Biology, 69th edition, 69: 429-433.

  35. Kim, J.K, , H. W. Gabel, R. S. Kamath, M. Tewari, A. Pasquinelli, S. Kennedy, M. Dybbs, N. Bertin, M. Vidal, J. M. Kaplan, and G. Ruvkun 2005. Functional genomic analysis of RNA interference in C. elegans. Science 308: 1164-7.

  36. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P. 2005. Analysis of xbx genes in C. elegans. Development. 132:1923-34.

  37. Hamilton, B. , Y. Dong, M. Shindo, W. Liu, G. Ruvkun, and S. S. Lee. 2005. A Systematic RNAi Screen for Longevity Genes in C. elegans. Genes and Development 19:1544-55.

  38. Sieburth, D, Q. Ch ng, M. Dybbs, M. Tavazoie, S. Kennedy, D. Wang, D. Dupuy, J. Rual, D. Hill, M. Vidal, G. Ruvkun, and J. Kaplan. 2005. Systematic analysis of genes required for synapse structure and function. Nature 436: 510-517.

  39. Wang, D. S. Kennedy, D. Conte, J. Kim, H. Gabel, R. Kamath, C. Mello, and G. Ruvkun. 2005. Somatic misexpression of germline P granules and enhanced RNA interference in C.elegans Retinoblastoma pathway mutants. Nature 436: 593-597.

  40. Frand, A.R., S. Russel, G. Ruvkun 2005. Genes essential for C. elegans molting revealed through a genome-wide RNA-interference screen. PLoS, 3:e312 [Epub ahead of print].

  41. Duchaine, T.F,, J. A. Wohlschlegel, S. Kennedy, Y. Bei, D. Conte,, K. Pang, D.R. Brownell, S. Harding, S. Mitani, G. Ruvkun, J. R. Yates, and C. C. Mello. 2006. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 124:343-54.

  42. Mak, H.Y., L.S. Nelson, M. Basson, C. D. Johnson and G. Ruvkun. 2006. Polygenic control of C. elegans fat storage. Nature Genetics 38:363-8.

  43. Sandoval, G.M., J. S. Duerr, J. Hodgkin, J. B. Rand & G. Ruvkun. 2006. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nature Neuroscience, 9:599-601.

  44. Hu, P.J., J. Xu, and G. Ruvkun. 2006. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul;2(7):e99.

  45. Hayes, G. D. A. R. Frand, and G. Ruvkun. 2006. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 133: 4631-4641.

  46. Ruvinsky, I., U. Ohler, C. B. Burge, and G. Ruvkun. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 2006 Sep 15.

  47. Hayes, GD and G. Ruvkun. Misexpression of the C. elegans miRNA let‑7 is sufficient to drive developmental programs. Cold Spring Harbor Symp Quant Biol. 2006;71:21-7. Regulatory RNAs.

  48. Curran, S. P. and G. Ruvkun. Lifespan regulation by evolutionarily conserved genes essential for viability. 2007. PloS Genetics, 2007 Apr 6;3(4):e56. Epub 2007 Feb 27.

  49. Kim N, Dempsey C, Kuan CJ, Zoval J, O'rourke E, Ruvkun G, Madou M, Sze J. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in C. elegans. Genetics. 2007 Aug 24; [Epub ahead of print]

  50. Samuelson, A. V. , Carr, C. E., and G. Ruvkun. 2007. Gene activities that mediate increased lifespan of C. elegans insulin-like signaling mutants. Genes and Development, Nov 15;21(22):2976-94.

  51. Parry, D.H., Xu, J. and G. Ruvkun. 2007. A whole-genome RNAi screen for C. elegans miRNA pathway genes. Current Biology, Nov 13; [Epub ahead of print]

  52. Isenbarger, T. A. , M. Finney, C. Ríos-Velázquez, J. Handelsman, and G. Ruvkun. Miniprimer PCR, a new lens for viewing the microbial world 2007. Applied and Environmental Microbiology, in press.

  53. Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. 2008 Evol Dev. Jan-Feb;10(1):106-13.
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