Founders
The Center for Computational and Integrative Biology was founded by a group of MGH researchers and Harvard professors. Click on any of the names to link to a page with more complete information about each of them.
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| Fred Ausubel |
Frederick M. Ausubel is Professor of Genetics at Harvard Medical School and the Ernst Winnacker Distinguished Investigator in the Department of Molecular Biology at Massachusetts General Hospital. Dr. Ausubel’s scientific work focuses primarily on host-microbe interactions.
Dr. Ausubel was elected to the National Academy of Sciences in 1994, the American Academy of Microbiology in 2002, and the American Academy of Arts and Sciences in 2003. In addition to serving on a variety of editorial boards, Dr. Ausubel is founding editor of the widely-read Current Protocols in Molecular Biology. |
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| Mason Freeman |
Dr. Freeman graduated from Harvard College and received his M.D. at the University of California, San Francisco in 1979. He served as an intern, resident, and endocrinology fellow in the Department of Medicine at the Massachusetts General Hospital and was Chief Resident in Medicine at the MGH in 1985. Following clinical training, he worked as a post-doctoral research fellow in the Biology Department of the Massachusetts Institute of Technology before returning to the MGH to head the Cardiovascular Health Center. He became Chief of the Lipid Metabolism Unit at the MGH in 1992. Mason’s research work has centered on the role of macrophages in atherosclerosis with particular interest in the trafficking of lipids through these cells. |
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| Brian Seed |
Dr. Seed is Director of the Center for Computational and Integrative Biology at the Massachusetts General Hospital and is Professor of Genetics at Harvard . A graduate of CalTech, he received both his B.S. and Ph.D. degrees there. Dr. Seed is the author of numerous publications molecular biology, genomics and proteomics. He holds numerous patents; see the CV for a list.
His laboratories include groups in automation, bioinformatics, chemistry, microarrays, proteomics, selection, sequencing and synthesis, in addition to his own Seed Lab.
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| Jack Szostak |
Dr. Szostak is an Investigator of the Howard Hughes Medical Institute, Professor of Genetics at Harvard Medical School, and the Alex Rich Distinguished Investigator in the Department of Molecular Biology at the Massachusetts General Hospital. His current research interests are in the laboratory synthesis of self-replicating systems and the origin of life. Dr. Szostak is a member of the National Academy of Sciences, and a Fellow of the New York Academy of Sciences and the American Academy of Arts and Sciences.
In 2000, Dr. Szostak was awarded the Medal of the Genetics Society of America. |
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| Ron Tompkins |
Ron Tompkins graduated Summa Cum Laude from Tulane University Medical School and holds a doctorate in chemical and biomedical engineering from the Massachusetts Institute of Technology.
Dr. Tompkins is the Chief of Burns Service at the Massachusetts General Hospital, is the John Frances Burke Professor of Surgery at Harvard Medical School, and serves as the Chief of Staff of Shriners Hospital for Children in Boston. Dr. Tompkins' primary research interests are in physiology of inflammation and burn healing.
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| Jia Wolfe |
Dr. Wolfe has extensive research and management experience in the biotech industry and has a special interest in drug discovery and interdisciplinary research in chemistry and biology. She currently directs a drug discovery group within the Center for Computational and Integrative Biology. An honors graduate of University of Science and Technology of China, Jia received broad training there, including chemistry, mathematics, physics, and statistics.
Dr. Wolfe has published many peer-reviewed research articles in prestigious chemistry and biology journals, and is an inventor of more than ten issued US patents. |
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| Ramnik Xavier |
Ramnik Xavier is Assistant Professor of Medicine at Harvard Medical School and attending physician in the Gastrointestinal Unit at Massachusetts General Hospital.
He is Board certified in Medicine and Gastroenterology. Following clinical training, he completed his post-doctoral fellowship with Brian Seed in the Department of Molecular Biology at the MGH Department of Genetics at Harvard Medical School. While in the Seed lab, Ramnik and his colleagues demonstrated that lipid rafts play an important role in T cell signaling. His current research focuses on PDZ proteins in cell signaling and genomic approaches for dissecting novel pathways in inflammation and cancer. |
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